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PROTAC FTO degrader 1

CAT: 0804-HY-175885Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175885Size:1 Each
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Description
PROTAC FTO degrader 1 is a Fat Mass and Obesity-associated Protein (FTO) PROTAC degrader. PROTAC FTO degrader 1 selectively degrades FTO depending on VHL E3 ligase and ubiquitin-proteasome system. PROTAC FTO degrader 1 can increase m6A modifications on mRNAs associated with ribosome biogenesis and promote their YTHDF2-mediated decay. PROTAC FTO degrader 1 can inhibit cancer cells proliferation and induce apoptosis. PROTAC FTO degrader 1 can be used for the research of cancer, such as acute myeloid leukemia (AML). (Structure Note: Pink: FTO ligand ; Blue: VHL ligand (HY-112078) ; Black: linker (HY-W002042) ; VHL ligand-Linker: (HY-139218) )
UNSPSC
12352005
Target
Apoptosis; Caspase; Fat Mass and Obesity-associated Protein (FTO) ; PARP; PROTACs; YTHDF
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics; Metabolic Enzyme/Protease; PROTAC
Field of Research
Cancer
Smiles
CC(C(OCOC(C1=C(C=CC=C1NC(C(Cl)=CC(C(C(C)=NO2)=C2C)=C3)=C3Cl)N4CCN(CC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N5C[C@H](O)C[C@H]5C(N[C@@H](C)C6=CC=C(C7=C(C)N=CS7)C=C6)=O)=O)=O)=O)CC4)=O)=O)C
Molecular Formula
C59H75Cl2N9O10S
Molecular Weight
1173.25
References & Citations
[1]Li W, et al. FTO degrader impairs ribosome biogenesis and protein translation in acute myeloid leukemia. Sci Adv. 2025 Aug 15;11 (33) :eadv7648.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 3; PARP1; von Hippel-Lindau (VHL) ; YTHDF2

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