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Ferroptosis-IN-17

CAT: 0804-HY-170509Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170509Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ferroptosis-IN-17 (Compound 18) is a ferroptosis (Ferroptosis) inhibitor with an EC50 value of 0.57 μM. Ferroptosis-IN-17 reduces intracellular ferrous ion accumulation, lipid peroxidation, and effectively restores the levels of glutathione (GSH) and glutathione peroxidase 4 (GPX4) . Ferroptosis-IN-17 shows good solubility and significant metabolic stability in rat plasma. Ferroptosis-IN-17 is promising for research in tumor suppression, neurodegenerative diseases, and cardiovascular diseases[1].
UNSPSC
12352005
Target
Ferroptosis; Glutathione Peroxidase
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease; Cardiovascular Disease
Smiles
O=C(NCC)C1=CC=C(NC2CCCCC2)C(NS(=O)(C3=CC=C([N+]([O-])=O)C=C3)=O)=C1
Molecular Formula
C21H26N4O5S
Molecular Weight
446.52
References & Citations
[1]Zhang NY, et al. Design, Synthesis, and Biological Evaluation of New Improved Ferrostatin-1 Derived Ferroptosis Inhibitors. Chem Biodivers. 2024 Oct 4:e202402141.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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