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Ferroptosis-IN-21

CAT: 0804-HY-W002942-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W002942-01Size:1 g
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Description
Ferroptosis-IN-21 is a ferroptosis inhibitor that protects against renal I/R injury by suppressing ferroptosis and directly scavenging peroxyl radicals. Ferroptosis-IN-21 displays broad-spectrum anti-ferroptotic efficacy across multiple inducers in renal tubular epithelial cells, with nanomolar potency and robust suppression of lipid Reactive Oxygen Species (ROS) . Ferroptosis-IN-21 significantly ameliorates renal I/R injury in mice, reducing histological damage, functional impairment, and inflammatory cytokine expression, while decreasing lipid peroxidation biomarkers such as 4-hydroxynonenal. Ferroptosis-IN-12 can be used for research in the field of ferroptosis-targeted drug development[1].
CAS Number
6640-50-2
Product Name Alternative
1,2,3,4-Tetrahydroquinolin-8-ol; 8-hydroxy-1,2,3,4-tetrahydroquinoline
UNSPSC
12352005
Hazard Statement
H302, H412
Target
Ferroptosis; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.88
Solubility
DMSO : ≥ 100 mg/mL
Smiles
OC1=CC=CC2=C1NCCC2
Molecular Formula
C9H11NO
Molecular Weight
149.19
Precautions
H302, H412
References & Citations
[1]Sheng XH, et al. Discovery of 8-hydroxy-tetrahydroquinoline ferroptosis inhibitors for the treatment of acute kidney injury. Bioorg Chem. 2025 Sep;164:108874.
Shipping Conditions
Room Temperature
Storage Conditions
RT, protect from light
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1,2,3,4-Tetrahydroquinolin-8-ol
CAS Number6640-50-2
PubChem CID241490
IUPAC Name1,2,3,4-tetrahydroquinolin-8-ol
Molecular FormulaC9H11NO
Molecular Weight149.19
XLogP1.9
Topological Polar Surface Area32.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Heavy Atom Count11
Formal Charge0
Complexity138
SMILES
C1CC2=C(C(=CC=C2)O)NC1
InChI
InChI=1S/C9H11NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1,3,5,10-11H,2,4,6H2
InChIKey
WYKWUPMZBGOFOV-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1,2,3,4-Tetrahydroquinolin-8-ol
CAS: 6640-50-2
CID: 241490
Formula: C9H11NO
MW: 149.19
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight149.19
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass149.084063974
Monoisotopic Mass149.084063974
Topological Polar Surface Area32.3 Ų
Heavy Atom Count11
Formal Charge0
Complexity138
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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