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DNA/TOP2A-IN-1

CAT: 0804-HY-175834Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175834Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNA/TOP2A-IN-1 is an inhibitor of DNA and TOP2A. DNA/TOP2A-IN-1 selectively binds to TOP2A, not TOP2B, and interacts with DNA and TOP2A to form a stable DM1-TOP2A-DNA ternary complex. DNA/TOP2A-IN-1 induces DNA damage, increases reactive oxygen species (ROS) and triggers apoptosis in triple-negative breast cancer (TNBC) cells. DNA/TOP2A-IN-1 disrupts microtubule distribution and induces cell cycle arrest. DNA/TOP2A-IN-1 shows strong antiproliferative activity and inhibits cell migration. DNA/TOP2A-IN-1 inhibits tumor growth and can be used for TNBC research[1].
UNSPSC
12352005
Target
Apoptosis; Microtubule/Tubulin; Reactive Oxygen Species (ROS) ; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=CC=C(C=C1)OC2=C(C(C)=NN2C)CNC(C3=CC4=C(C(C5=CC=C(C=C5)OC)=N3)NC6=CC=CC=C64)=O
Molecular Formula
C32H29N5O4
Molecular Weight
547.60
References & Citations
[1] Xu X, et al. Novel β-carboline derivatives show promise as dual-target inhibitors of DNA and TOP2A for the treatment of triple negative breast cancer. Eur J Med Chem. 2025 Nov 15;298:118041.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II

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