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DNA/TOP2A-IN-1

CAT: 0013-GTR19273134-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273134-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DNA/TOP2A-IN-1 functions as an inhibitor of DNA and TOP2A. It binds selectively to TOP2A instead of TOP2B and interacts with DNA to form a stable DM1-TOP2A-DNA ternary complex. This compound induces DNA damage, elevates reactive oxygen species (ROS), and triggers apoptosis in triple-negative breast cancer (TNBC) cells. Additionally, DNA/TOP2A-IN-1 disrupts microtubule distribution and induces cell cycle arrest while exhibiting potent antiproliferative activity and inhibiting cell migration. It effectively suppresses tumor growth and is a valuable agent for TNBC research.
Storage Conditions
-20°C
Notes
For research use only.

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