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PRMT1-IN-3

CAT: 0013-GTR19273133-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19273133-01Size:10 mg
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Description
PRMT1-IN-3 is a potent inhibitor of protein arginine methyltransferase 1 (PRMT1) with an IC50 of 4.11 μM. It also inhibits PRMT6 and PRMT8, with IC50 values of 23.3 and 30.1 μM, respectively. In triple-negative breast cancer (TNBC) cells, PRMT1-IN-3 reduces asymmetric dimethylarginine (ADMA) levels and the histone modification H4R3me2a. It induces cell cycle arrest and apoptosis in MDA-MB-231 cells and inhibits cell migration and colony formation. Furthermore, PRMT1-IN-3 serves as a chemosensitizer for Paclitaxel and is applicable in TNBC research.
CAS Number
892570-48-8
Smiles
FC1=CC=C (C=C1) COC=2C=CC=CC2CNCCCNC
Molecular Formula
C18H23FN2O
Molecular Weight
302.39
Storage Conditions
-20°C
Notes
For research use only.

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