CHI3L1-IN-4

CAT: 0804-HY-175781Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-175781Size:1 Each

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Description

CHI3L1-IN-4 (Compound 8) is a Chitinase-3-Like Protein 1 (CHI3L1) inhibitor with a Kd of 6.8 μM. CHI3L1-IN-4 significantly reduces glioblastoma (GBM) spheroids viability and attenuates phospho-STAT3 levels by disrupting CHI3L1 pathway. CHI3L1-IN-4 can be used for GBM research[1].

CAS Number

1258696-85-3

UNSPSC

12352005

Target

Glycosidase; STAT

Related Pathways

JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Field of Research

Cancer

Smiles

CSC1=NN=C(S1)CNC(C2=CC=CC=C2)C3=CC=CC=C3

Molecular Formula

C17H17N3S2

Molecular Weight

327.47

References & Citations

[1]Kaur B, et al. Virtual Screening-Guided Discovery of Small Molecule CHI3L1 Inhibitors with Functional Activity in Glioblastoma Spheroids. bioRxiv [Preprint]. 2025 Aug 1:2025.07.31.667816.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

STAT3

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