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CHI3L1-IN-3

CAT: 0804-HY-175207-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175207-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CHI3L1-IN-3 is a CHI3L1 inhibitor. CHI3L1-IN-3 binds to CHI3L1 with Kds of 13.76 μM and 13.5 μM in MST and SPR assays, respectively. CHI3L1-IN-3 demonstrates extended plasma half-lives and microsomal stability, along with reduced intrinsic clearance. CHI3L1-IN-3 induces dose-dependent cytotoxicity, reduces spheroid mass and inhibits migration in a 3D multicellular glioblastoma (GBM) spheroid model. CHI3L1-IN-3 can be used for the study of GBM[1].
UNSPSC
12352005
Target
Glycosidase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Purity
98.95
Smiles
COC(C(OC)=C1)=CC(C2=O)=C1N=C(SCC(NC3=CC=C(CC)C=C3)=O)N2CCC4=CC=C(OC)C(OC)=C4
Molecular Formula
C30H33N3O6S
Molecular Weight
563.66
References & Citations
[1]Kaur B, et al. Lead optimization of a CHI3L1 inhibitor for Glioblastoma: Enhanced target engagement, pharmacokinetics, and efficacy in 3D spheroid models. Eur J Med Chem. 2025 Jun 28;297:117924.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature, keep dry and cool
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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