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TFAM activator 1

CAT: 0804-HY-175739-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175739-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TFAM activator 1 (Compound 2) is a Transcription Factor A, Mitochondrial (TFAM) activator. TFAM activator 1 has an anti-inflammatory and mitochondrial dysfunction restoration activity. TFAM activator 1 increases TFAM protein levels and mtDNA copy number and inhibits mtDNA stress-mediated inflammatory responses with reduced cytokine (TNF-α, CXCL-10 and IFN) production by preventing mtDNA escape into the cytosol. TFAM activator 1 significantly increases ATP level, reduces fibrotic markers and enhances Treg 240 function. TFAM activator 1 can be used for mitochondrial dysfunction, such as Parkinson’s and Alzheimer’s diseases research[1].
CAS Number
932992-44-4
UNSPSC
12352005
Target
CXCR; IFNAR; Mitochondrial Metabolism; TNF Receptor
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Smiles
CN1C(OC2=CC(S(=O)(N3CCC(CC3)C4=CC=NC=C4)=O)=CC=C21)=O
Molecular Formula
C18H19N3O4S
Molecular Weight
373.43
References & Citations
[1]Lyu L, et al. Suppression of interferon signaling via small molecule modulation of TFAM[J]. bioRxiv, 2025: 2025.08. 13.670134.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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