Factor XI-IN-2

CAT: 0804-HY-175735Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175735Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus[1].
CAS Number
[2563884-39-7]
UNSPSC
12352005
Target
Factor XI
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
O=C(N1CCCCC1)C2=CC(C(N3CCC(CC3)N4C=CC=N4)=O)=NC5=CC=C(C=C52)OCC6=CC=C7SN=NC7=C6
Molecular Formula
C31H31N7O3S
Molecular Weight
581.69
References & Citations
[1]Ellsworth, Ken, et al. The Discovery of a Novel Anticoagulant Mechanism: Factor XI Activation Inhibitors. ACS Pharmacology & Translational Science (2025) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4

Related Products

CatalogName
HY-143477Factor XI-IN-1
HY-P72188-01Coagulation Factor XI/F11, Human (His)
HY-P703765Coagulation factor XI, Cynomolgus (HEK293, His)
HY-P700978-01Coagulation Factor XI/F11, Cynomolgus (HEK293, His)
HY-P73046-01Coagulation Factor XI/F11, Human (HEK293, His)
HY-P703948Coagulation Factor XI/F11, Rabbit (HEK293, His)
HY-N6803-01Polygalaxanthone XI
HY-P5872Jingzhaotoxin XI
HY-N13576Karaviloside XI
HY-N10793-01RA-XI

Alternative Products

CatalogName
sc-365996Factor XI (G-2)
GWB-533EF1Factor XI
sc-365996 ACFactor XI (G-2) AC
sc-365996 HRPFactor XI (G-2) HRP
sc-365996 FITCFactor XI (G-2) FITC
sc-365996 PEFactor XI (G-2) PE
AP78696-01Coagulation factor XI
MBS635177-01Factor XI, Human
MBS6124652-01Factor XI (AP)
MBS5805909Factor XI-IN-1

Popular Products