Factor XI-IN-2

• Description:

  Factor XI-IN-2 is a Factor XI activation inhibitor with an IC50 of 20 nM. Factor XI-IN-2 does not directly inhibit the enzymatic activity of FXIa, but specifically binds to the FXI enzyme precursor and allosterically inhibits the process by which it is activated by FXIIa. Factor XI-IN-2 inhibits thrombosis in the rabbit arteriovenous (AV) shunt thrombosis model. Factor XI-IN-2 can be used for the study of antithrombus[1].

• UNSPSC:

  12352005

• Target:

  Factor XI

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Cardiovascular Disease

• Smiles:

  O=C(N1CCCCC1)C2=CC(C(N3CCC(CC3)N4C=CC=N4)=O)=NC5=CC=C(C=C52)OCC6=CC=C7SN=NC7=C6

• Molecular Formula:

  C31H31N7O3S

• Molecular Weight:

  581.69

• References & Citations:

  [1]Ellsworth, Ken, et al. The Discovery of a Novel Anticoagulant Mechanism: Factor XI Activation Inhibitors. ACS Pharmacology & Translational Science (2025) .

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 4

• CAS Number:

  [2563884-39-7]