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E3 ligase Ligand 67

CAT: 0804-HY-175686-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175686-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
E3 ligase Ligand 67 (Compound 5) is a STUB1/CHIP ligand with a Kd of 8.9 μM for CHIP in fluorescence polarization assay. E3 ligase Ligand 67 is an E3 ligase ligand that can be used for synthesis of PROTACs[1].
UNSPSC
12352100
Target
Ligands for E3 Ligase
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=S(C[C@@H]1CN(C(C2=CNC3=C2C(F)=C(F)C(F)=C3F)=O)CCC1)(N(C)C)=O
Molecular Formula
C17H19F4N3O3S
Molecular Weight
421.41
References & Citations
[1]Lucas SCC, et al. Discovery of Small-Molecule Ligands for the E3 Ligase STUB1/CHIP from a DNA-Encoded Library Screen. ACS Med Chem Lett. 2025 Aug 5;16 (8) :1445-1451.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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