ML210-ansaFc

CAT: 0804-HY-175633Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175633Size:1 Each
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Description
ML210-ansaFc (Compound III-13) is a covalent GPX4 inhibitor with a [3]-ferrocenophane group (IC50 of 3.4 μM) . ML210-ansaFc potently induces ferroptosis by increasing the level of ROSand promoting lipid peroxidation (LPO) in cancers cells. ML210-ansaFc has an anticancer activity and suppresses tumor growth in tumor 3D spheroids. ML210-ansaFc can be used for cancer therapy resistance research[1].
UNSPSC
12352100
Target
Ferroptosis; Glutathione Peroxidase; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=CSC(C#C)=N1)N2CCN(CC2)C(CCc3cccc3)c4cccc4.[][Fe][]
Molecular Formula
C23H23FeN3OS
Molecular Weight
445.36
References & Citations
[1]Wang J, et al. Diversity-Oriented Synthesis toward the Discovery of Ferrocenophane-Appended GPX4 Inhibitors as Potent Ferroptosis Inducers with Drug Likeness. J Med Chem. 2025 Aug 14;68 (15) :15828-15848.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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