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ML213

CAT: 0804-HY-101843-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-101843-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ML213 is a selective activator of Kv7.2 and Kv7.4 channels, enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively.
CAS Number
[489402-47-3]
UNSPSC
12352005
Hazard Statement
H315, H319, H335, H413
Target
Potassium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ML213.html
Purity
99.76
Solubility
DMSO : 36.67 mg/mL (ultrasonic)
Smiles
O=C(C1C(C2)CCC2C1)NC3=C(C)C=C(C)C=C3C
Molecular Formula
C17H23NO
Molecular Weight
257.37
Precautions
H315, H319, H335, H413
References & Citations
[1]Brueggemann LI, et al. Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol Pharmacol. 2014 Sep;86 (3) :330-41.|[2]Jepps TA, et al. Vasorelaxant effects of novel Kv 7.4 channel enhancers ML213 and NS15370. Br J Pharmacol. 2014 Oct;171 (19) :4413-24.|[3]Yu H, et al. Discovery, Synthesis, and Structure Activity Relationship of a Series of N-Aryl- bicyclo[2.2.1]heptane-2-carboxamides: Characterization of ML213 as a Novel KCNQ2 and KCNQ4 Potassium Channel Opener. ACS Chem Neurosci. 2011 Oct 19;2 (10) :572-577.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

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MBS3607516-01ML213
A20068-50ML213 50mg
A20068-100ML213 100mg
A20068-5ML213 5mg
A20068-25ML213 25mg
A20068-2ML213 2mg
A20068-10ML213 10mg
A20068-10mM-DML213 10mM * 1mL in DMSO

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