ML210

CAT: 0498-bs-82747C-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82747C-01Size:10 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
ML210 is selectively synthetic lethal to HRAS expressing cells compared to isogenic non-HRAS cells (IC50 = 7.1 nM for BJeLR (expressing HRASg12v) cells vs IC50 = 272 nM for BJeH-LT (non-HRAS expressing) cells.1 ML210 is able to inhibit glutathione peroxidase 4 (GPX4), an important selenoenzyme that protects cells from ferroptosis caused by iron catalyzed formation of free radicals from lipid peroxides.2,3 Treatment of several treatment-resistant cancer cell lines exhibiting a high mesenchymal state with ML210 resulted in selective induction of ferroptosis.3
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
RT

Related Products

CatalogName

Alternative Products

CatalogName
abx282932-01ML210
HY-175633ML210-ansaFc
TBI4002-50MGML210, GPX4 inhibitor; Ferroptosis Inducer

Popular Products