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RSL3-NH2

CAT: 0804-HY-175615Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175615Size:1 Each
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Description
RSL3-NH2 is a GPX4 inhibitor and Ferroptosis inducer. RSL3-NH2 can be used as a cytotoxic payload for synthesis of antibody-drug conjugates (ADCs) [1].
CAS Number
3051815-39-2
UNSPSC
12352100
Target
ADC Payload; Ferroptosis; Glutathione Peroxidase
Related Pathways
Antibody-drug Conjugate/ADC Related; Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
NC(C=C1)=CC=C1[C@H](N2C(CCl)=O)C(NC3=C4C=CC=C3)=C4C[C@@H]2C(OC)=O
Molecular Formula
C21H20ClN3O3
Molecular Weight
397.85
References & Citations
[1]Zhang Y, et al. Development of a bispecific CDH17-GUCY2C ADC bearing the ferroptosis inducer RSL3 for the treatment of colorectal cancer. Cell Death Discov. 2025 Jul 28;11 (1) :347.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
GPX4

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