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EGFR-IN-169

CAT: 0804-HY-175531Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175531Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
EGFR-IN-169 is an epidermal growth factor (EGFR) (IC50 = 5.19 μM) inhibitor form panaxadiol. EGFR-IN-169 interferes with the migration and growth of colorectal cancer cells by inhibiting EGFR-mediated RalA/EMT pathway. EGFR-IN-169 shows an IC50 value of 4.46 μM and SI of 16.92 for HCT-116 cells. EGFR-IN-169 inhibits CDKs activity, induces G0/G1 cycle arrest and inhibits migration and invasion. EGFR-IN-169 reduces mitochondrial membrane potential and induces apoptosis and ROS production. EGFR-IN-169 can be used for the research of cancer, such as colorectal cancer[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; CDK; EGFR; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
O=C(C1=C(N2CC(O[C@@H]3C(C)(C)C(CC[C@]4(C)C5CC(O)C6[C@@]4(C)CCC6[C@@]7(C)CCCC(C)(C)O7)[C@]5(C)CC3)=O)C(Cl)=CC=C1)C2=O
Molecular Formula
C40H56ClNO6
Molecular Weight
682.33
References & Citations
[1]Tan H, et al. A novel 20 (R) dammarane panaxadiol-indole-2 ',3' -dione derivative was found to inhibit the growth and migration of colorectal cancer cells by inhibiting EGFR-mediated RalA/EMT pathway. Eur J Med Chem. 2025 Nov 15;298:118005.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1

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