Products for Research Use Only
RegisterLogin

EGFR-IN-169

CAT: 0931-T212564-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0931-T212564-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
ROS, Bcl-2 Family, Apoptosis, EGFR, CDK
Related Pathways
Apoptosis, Cell Cycle/Checkpoint, Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Immunology/Inflammation
Bioactivity
EGFR-IN-169 is an epidermal growth factor receptor (EGFR) inhibitor derived from ginsenoside, with an IC50 of 5.19 μM. It disrupts colorectal cancer cell migration and growth by inhibiting the EGFR-mediated RalA/EMT pathway. With an IC50 of 4.46 μM against HCT-116 cells and a selectivity index (SI) of 16.92, EGFR-IN-169 also inhibits CDKs, induces G0/G1 cell cycle arrest, and suppresses cell migration and invasion. Additionally, EGFR-IN-169 reduces mitochondrial membrane potential, induces apoptosis and reactive oxygen species (ROS) production. It is applicable in cancer research, particularly for colorectal cancer.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Related Products

CatalogName
T27069-01CPI-169
T7661-01SD-169
T85659-01Antibacterial agent 169
T210150-01Antitumor agent-169
T6809-01CPI-169 racemate
T76496-01Prepro-TRH- (160-169)
TP3194-01Mage-1 Antigen (161-169), human
T206551-01E3 Ligase Ligand-linker Conjugate 169
T9901A-629-01Anti-mouse CD8α Antibody (YTS 169.4)
T70324-01EGFR-IN-557

Alternative Products

CatalogName
HY-175531EGFR-IN-169
MBS131450PBTZ169 (PBTZ 169; PBTZ-169)
C5850-25SD 169
B4678-50CPI-169
HY-W015445-01SD-169
bs-6527C-01PBTZ-169

Popular Products