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DHC-286

CAT: 0804-HY-175334-02Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-175334-02Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia[1].
CAS Number
2920443-08-7
UNSPSC
12352005
Target
Molecular Glues
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(NCC1=CC=CC=C1C(F)(F)F)COC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3)=O)C=C2
Molecular Formula
C23H20F3N3O5
Molecular Weight
475.42
References & Citations
[1]Chase DH, et al. Design and Application of Cereblon-Recruiting Prodegraders. J Am Chem Soc. 2025 Jul 16;147 (28) :24527-24537.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxy]-N-[[2-(trifluoromethyl)phenyl]methyl]acetamide
CAS Number2920443-08-7
PubChem CID167885243
IUPAC Name2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxy]-N-[[2-(trifluoromethyl)phenyl]methyl]acetamide
Molecular FormulaC23H20F3N3O5
Molecular Weight475.4
XLogP1.9
Topological Polar Surface Area105
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity820
SMILES
C1CC(=O)NC(=O)C1N2CC3=C(C2=O)C=CC(=C3)OCC(=O)NCC4=CC=CC=C4C(F)(F)F
InChI
InChI=1S/C23H20F3N3O5/c24-23(25,26)17-4-2-1-3-13(17)10-27-20(31)12-34-15-5-6-16-14(9-15)11-29(22(16)33)18-7-8-19(30)28-21(18)32/h1-6,9,18H,7-8,10-12H2,(H,27,31)(H,28,30,32)
InChIKey
QSQUGTGYZORTAY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-[[2-(2,6-dioxopiperidin-3-yl)-1-oxo-3H-isoindol-5-yl]oxy]-N-[[2-(trifluoromethyl)phenyl]methyl]acetamide
CAS: 2920443-08-7
CID: 167885243
Formula: C23H20F3N3O5
MW: 475.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight475.4
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass475.13550523
Monoisotopic Mass475.13550523
Topological Polar Surface Area105 Ų
Heavy Atom Count34
Formal Charge0
Complexity820
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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