DHC-286

• Description:

  DHC-286 is a molecular glue degrader targeting GSPT1. DHC-286 recruits GSPT1 to the CRL4CRBN ubiquitin ligase complex, promoting GSPT1 ubiquitination and proteasomal degradation, inducing cytotoxicity. DHC-286 is promising for research of cancers such as acute myeloid leukemia[1].

• UNSPSC:

  12352005

• Target:

  Molecular Glues

• Related Pathways:

  PROTAC

• Field of Research:

  Cancer

• Smiles:

  O=C(NCC1=CC=CC=C1C(F)(F)F)COC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3)=O)C=C2

• Molecular Formula:

  C23H20F3N3O5

• Molecular Weight:

  475.42

• References & Citations:

  [1]Chase DH, et al. Design and Application of Cereblon-Recruiting Prodegraders. J Am Chem Soc. 2025 Jul 16;147 (28) :24527-24537.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2920443-08-7]