αMβ2 integrin agonist-1

• Description :

  αMβ2 integrin agonist-1 (Compound 8) is a highly selective αMβ2 integrin agonist with anti-inflammatory activity (EC50=1.4 nM) . αMβ2 integrin agonist-1 activates integrin-mediated cell adhesion and JNK/ERK signaling. αMβ2 integrin agonist-1 induces tumor-associated macrophage repolarization and enhances antitumor T-cell immune responses. αMβ2 integrin agonist-1 is promising for research of cancers and chronic inflammatory diseases (e.g., pancreatic cancer, rheumatoid arthritis) [1].

• UNSPSC :

  12352005

• Target :

  ERK; Integrin; JNK

• Related Pathways :

  Cytoskeleton; MAPK/ERK Pathway; Stem Cell/Wnt

• Field of Research :

  Cancer; Inflammation/Immunology

• Smiles :

  [NH3+]C1=CC=C(C=C1)CNC(N[C@H](C(O)=O)CC(O)=O)=O.O=C([O-])C(F)(F)F

• Molecular Formula :

  C14H16F3N3O7

• Molecular Weight :

  395.29

• References & Citations :

  [1]Giraldi V, et al. Targeting α4β1 integrin: from cyclic to linear ligands, effects of chemical modifications. Eur J Med Chem. 2025 Nov 5;297:117965.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported