BAL-1516

• Description:

  BAL-1516 is a brain-penetrant and highly selective NLRP3 inhibitor (IC50=14.2 nM) . BAL-1516 significantly suppresses IL-1β and IL-18 release in microglial neuroinflammation models (IC50=11-59 nM) . BAL-1516 is promising for research of neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s) and systemic inflammatory disorders[1].

• UNSPSC:

  12352005

• Target:

  NOD-like Receptor (NLR)

• Related Pathways:

  Immunology/Inflammation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Smiles:

  CCOC1=CC(C(N([C@@H](C2=CN=C(C3=C2NN=C3)C)C)C)=O)=CC=C1C4=NC(C)=CS4

• Molecular Formula:

  C23H25N5O2S

• Molecular Weight:

  435.54

• References & Citations:

  [1]Torp J, et al. Inhibition of NLRP3 by a CNS-penetrating indazole scaffold[J]. bioRxiv, 2025: 2025.07. 01.662566.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  NLRP3