S-15176

CAT: 0804-HY-172227Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-172227Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
S-15176 is an inhibitor of the mitochondrial permeability transition pore (PTP) . S-15176 inhibits mitochondrial swelling induced by tert-butylhydroperoxide with an IC50 value of 45.7 μM. S-15176 inhibits PTP opening, prevents mitochondrial membrane potential dissipation and NAD (P) H oxidation, and increases mitochondrial calcium loading capacity. S-15176 is promising for research of ischemia-reperfusion injury[1][2].
CAS Number
[148089-70-7]
UNSPSC
12352005
Target
Mitochondrial Metabolism
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cardiovascular Disease
Smiles
OC1=C(C(C)(C)C)C=C(SCCCN2CCN(CC2)CC3=CC=C(C(OC)=C3OC)OC)C=C1C(C)(C)C
Molecular Formula
C31H48N2O4S
Molecular Weight
544.79
References & Citations
[1]Albengres E, et al. S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes. Fundam Clin Pharmacol. 2001 Feb;15 (1) :41-6.|[2]Elimadi A, et al. S-15176 inhibits mitochondrial permeability transition via a mechanism independent of its antioxidant properties. Eur J Pharmacol. 2003 May 9;468 (2) :93-101.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-125845B(S, S, S) -AHPC
HY-120217A(S, S, S) -VH032
HY-172298(R, S, S, S) -Orlistat
HY-112078B(S, S, S) -AHPC-Me
HY-125845A-01(S, S, S) -AHPC (hydrochloride)
HY-123109A-01(S, S, S) -AHPC-Boc
HY-78931B-01(S, S, S, S, R) -Boc-Dap-NE
HY-B0010C(S, S) -Formoterol
HY-130671B(S, S) -DPPG
HY-122715(S, S) -D211

Alternative Products

CatalogName
MF-0115477-01S-15176
MF-0142693-01S-15176 difumarate
sc-215828AS-15176 difumarate salt
465057-01(S, S, S, S) -Nebivolol
TRC-N381313-50MG(S,S,S,S)-Nebivolol
465056S, S, S, S, S-Trandolapril Hydrochloride
TRC-T713490-1GS,S,S,S,S-Trandolapril Hydrochloride
465061(+) - (S, S, S) -Ciramadol
465059(S, S, S) -Aprepitant
TRC-C490005-100MG(+)-(S,S,S)-Ciramadol

Popular Products