m-PEG8-DBCO

• UNSPSC Description:

  m-PEG8-DBCO is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG8-DBCO is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

• Target Antigen:

  PROTAC Linkers

• Type:

  Reference compound

• Related Pathways:

  PROTAC

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/m-peg8-dbco.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(CCC(NCCOCCOCCOCCOCCOCCOCCOCCOC)=O)N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2

• Molecular Weight:

  670.79

• References & Citations:

  [1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported