Anticancer agent 276

CAT: 0804-HY-175171Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-175171Size:1 Each
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Description
Anticancer agent 276 (Compound 5) is a multi-target anticancer agent. Anticancer agent 276 has a potent anticancer activity against human tumor cells with IC50s of 6.90 and 4.48 μM for HEPG2 and MCF7 cells, respectively. Anticancer agent 276 shows strong and stable interactions across multiple targets, including Topoisomerase II, VEGFR2, c-Met, EGFR and ERα[1].
UNSPSC
12352005
Target
C-Met/HGFR; EGFR; Estrogen Receptor/ERR; Topoisomerase; VEGFR
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
NN1C(C2=C(N=C1[C@H]3CC(C4=CC=CC=C4)=NN[C@H]3C5=CC=CC=C5)C=CC=C2)=O
Molecular Formula
C24H21N5O
Molecular Weight
395.46
References & Citations
[1]Haneen DSA, et al. Synthesis, comprehensive in silico studies, and cytotoxicity evaluation of novel quinazolinone derivatives as potential anticancer agents. Sci Rep. 2025 Jul 3;15 (1) :23697.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ERα; Topo II; VEGFR2/KDR/Flk-1

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