Anticancer agent 276

• Description :

  Anticancer agent 276 (Compound 5) is a multi-target anticancer agent. Anticancer agent 276 has a potent anticancer activity against human tumor cells with IC50s of 6.90 and 4.48 μM for HEPG2 and MCF7 cells, respectively. Anticancer agent 276 shows strong and stable interactions across multiple targets, including Topoisomerase II, VEGFR2, c-Met, EGFR and ERα[1].

• UNSPSC :

  12352005

• Target :

  C-Met/HGFR; EGFR; Estrogen Receptor/ERR; Topoisomerase; VEGFR

• Related Pathways :

  Cell Cycle/DNA Damage; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Vitamin D Related/Nuclear Receptor

• Field of Research :

  Cancer

• Smiles :

  NN1C(C2=C(N=C1[C@H]3CC(C4=CC=CC=C4)=NN[C@H]3C5=CC=CC=C5)C=CC=C2)=O

• Molecular Formula :

  C24H21N5O

• Molecular Weight :

  395.46

• References & Citations :

  [1]Haneen DSA, et al. Synthesis, comprehensive in silico studies, and cytotoxicity evaluation of novel quinazolinone derivatives as potential anticancer agents. Sci Rep. 2025 Jul 3;15 (1) :23697.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  ERα; Topo II; VEGFR2/KDR/Flk-1