Products for Research Use Only
RegisterLogin

WMJ-J-09

CAT: 0804-HY-174803-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-174803-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
WMJ-J-09 is an HDAC inhibitor with IC50 values of 7.5 nM (HDAC1), 21.3 nM (HDAC2), 18.4 nM (HDAC3), 90.9 nM (HDAC8), 3.9 nM (HDAC6) and 8715.7 nM (HDAC4) . WMJ-J-09 blocks the cell cycle and induces apoptosis in cancer cells. WMJ-J-09 induces cancer cell death through the LKB1-AMPK-p38MAPK-p63-survivin signaling cascade.WMJ-J-09 inhibits HDAC enzyme activity, leading to acetylation of key proteins and thereby regulating cancer cell death. WMJ-J-09 can be used in HCT116 cells and FaDu cells research[1][2].
CAS Number
2416914-29-7
UNSPSC
12352100
Target
AMPK; Apoptosis; HDAC; MDM-2/p53; Microtubule/Tubulin; p38 MAPK; Pim; Survivin
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Cytoskeleton; Epigenetics; JAK/STAT Signaling; MAPK/ERK Pathway; PI3K/Akt/mTOR
Field of Research
Cancer
Purity
98.44
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NO)CCCCCCC(NC1=CC(N(S(C2=CC=CC=C2)(=O)=O)CC3)=C3C=C1)=O
Molecular Formula
C22H27N3O5S
Molecular Weight
445.53
References & Citations
[1]Hanhuang Yu, et al. The hydroxamate based HDAC inhibitor WMJ-J-09 induces |[2]Chia-Sheng Yen, et al. A Novel Hydroxamate-Based Compound WMJ-J-09 Causes Head and Neck Squamous Cell Carcinoma Cell Death via LKB1-AMPK-p38MAPK-p63-Survivin Cascade. Front Pharmacol. 2018 Mar 1. 9:167.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-149263HAA-09
HY-P1439-01RS 09
HY-103666-01CY-09
HY-16704-01ESI-09
HY-12840-01OBA-09
HY-165298-01DGY-09-192
HY-128113-01AG-09/1
HY-P1439A-01RS 09 (TFA)
HY-111247-01Ro 09-0680
HY-118580RO-09-4609

Alternative Products

CatalogName
GTR19272696-01WMJ-J-09
133169SCN-09-J ClipSleeve Markers
333169SCNG-09-J AB Labels
B4814-5ESI-09
BA6234-5OBA-09
ZHC56636-01RS 09
T4164-01CY-09
255266-01ESI 09
MBS3601836MPK-09

Popular Products