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PARP1-IN-39

CAT: 0804-HY-174446Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174446Size:1 Each
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Description
PARP1-IN-39 is an inhibitor of PARP1 with an IC50 of 0.22 nM. PARP1-IN-39 has an IC50 of 1.57 nM in human breast cancer cells. PARP1-IN-39 can be studied in breast, ovarian, pancreatic, and prostate cancers associated with DNA repair deficiencies, such as BRCA1/2 mutations[1].
CAS Number
3054988-47-2
UNSPSC
12352005
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CCNC(C1=CC=C(N2C=C3CN(CC3=N2)CC4=C(C5=C(N6N=CC(F)=C6C(N5)=O)C=C4)F)C(F)=N1)=O
Molecular Formula
C24H19F3N8O2
Molecular Weight
508.46
References & Citations
[1]Xin Zhou and Steven H. Liang (2025) . Synthesis of Novel Substituted N-Heterocycles and Their Use of Selective Poly (ADP-ribose) Polymerase 1 (PARP1) Inhibitors. ACS Med. Chem. Lett. 2025, 16, 7, 1254–1255.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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