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PARP1-IN-37

CAT: 0931-T206871-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206871-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
952474-39-4
Target
PARP
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic
Bioactivity
PARP1-IN-37 (Compound 8) is an orally active and selective inhibitor of poly (ADP-ribose) polymerases 1 and 2 (PARP1/2), with an IC50 value of 24 nM for PARP1. It inhibits PARP activity in cells with an EC50 value of 3.7 μM and holds potential for research on BRCA-mutated tumors, such as breast and ovarian cancers.
Smiles
O=C(N)C1=CC=CC2=CN(N=C21)C=3C=CC=CC3
Molecular Formula
C14H11N3O
Molecular Weight
237.257
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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