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PeS-9

CAT: 0804-HY-174377Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-174377Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PeS-9 is an Androgen Receptor (AR) degrader that induces androgen receptor degradation PeS-9 induces mitochondrial and ER stress by promoting cytotoxic ROS production, leading to the release of mitochondrial cytochrome C and AIF. PeS-9 subsequently activates caspases-9 and -3, causing DNA fragmentation and apoptotic cell death. PeS-9 has anticancer activity against prostate cancer and exerts in vivo antitumor and antimetastatic activity with minor side effects. PeS-9 can be used for the study of targeting monotherapy against GLUT-1-overexpressing tumors[1].
UNSPSC
12352100
Target
Androgen Receptor; Apoptosis; Calcium Channel; Caspase; Cytochrome P450; GLUT; Mitochondrial Metabolism; p38 MAPK; Reactive Oxygen Species (ROS)
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; NF-κB; Vitamin D Related/Nuclear Receptor
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
COC1=C(CSC[C@H]2O[C@H]([C@@H]([C@H]([C@@H]2OC(C)=O)OC(C)=O)OC(C)=O)OC(C)=O)C(C3=C(C=CC=C3O)C1=O)=O
Molecular Formula
C26H28O13S
Molecular Weight
580.56
References & Citations
[1]Busenbender T, et al. 6- ((1,4-naphthoquinone-2-yl) methyl) thio-glucose conjugates, a novel targeted approach for advanced prostate cancer. Mol Cancer Ther. 2025 Apr 29.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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