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PeS-9

CAT: 0931-T210924-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210924-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Transporter, Calcium Channel, Cytochromes P450, Apoptosis, p38 MAPK, Caspase, Mitochondrial Metabolism, ROS
Related Pathways
Metabolism, MAPK, Membrane transporter/Ion channel, Proteases/Proteasome, Apoptosis, Immunology/Inflammation
Bioactivity
PeS-9 is an androgen receptor (AR) degrader that induces the degradation of androgen receptors. It enhances the production of cytotoxic reactive oxygen species (ROS), leading to mitochondrial and endoplasmic reticulum stress, which results in the release of mitochondrial cytochrome C and AIF. PeS-9 activates caspase-9 and caspase-3, causing DNA fragmentation and apoptosis. It exhibits anti-prostate cancer activity and demonstrates antitumor and antimetastatic effects in vivo with minimal side effects. PeS-9 is applicable for targeted therapy research in GLUT-1 overexpressing tumors.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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