YO-PRO-1

• Description:

  YO-PRO-1 is a non-cell-membrane-penetrating green fluorescent dye. YO-PRO-1 cannot penetrate normal cell membranes but can penetrate the membranes of apoptotic and necrotic cells. YO-PRO-1 has a high affinity for DNA. When it is not bound to DNA, it emits almost no fluorescence, and when it binds to DNA, it can emit green fluorescence (Ex/Em: 488/530±30 nM) . YO-PRO-1 is often used together with Propidium Iodide (HY-D0815) to analyze and identify apoptotic and necrotic cells[1][2].

• UNSPSC:

  12171500

• Hazard Statement:

  H301, H315, H319

• Target:

  Fluorescent Dye

• Type:

  Dye Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/yo-pro-1.html

• Purity:

  98.20

• Solubility:

  10 mM in DMSO

• Smiles:

  C[N+](CCC[N+]1=C2C=CC=CC2=C(/C=C3OC4=CC=CC=C4N\3C)C=C1)(C)C.[I-].[I-]

• Molecular Formula:

  C24H29I2N3O

• Molecular Weight:

  629.32

• Precautions:

  H301, H315, H319

• References & Citations:

  [1]Boffa DJ, et al. Measurement of apoptosis of intact human islets by confocal optical sectioning and stereologic analysis of YO-PRO-1-stained islets. Transplantation. 2005 Apr 15;79 (7) :842-5.|[2]Fujisawa S, et al. Evaluation of YO-PRO-1 as an early marker of apoptosis following radiofrequency ablation of colon cancer liver metastases. Cytotechnology. 2014 Mar;66 (2) :259-73.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Dye Reagents

• Clinical Information:

  No Development Reported

• CAS Number:

  [152068-09-2]