GT-02216

• Target:

  Glycosidase

• Related Pathways:

  Metabolism

• Bioactivity:

  GT-02216 is capable of binding allosterically to GCase, thereby enhancing its function. In primary human fibroblasts, it increases GCase activity and decreases Tau accumulation in mutant GBA1 fibroblasts. Additionally, GT-02216 offers protection to hippocampal primary neurons exposed to Tau oligomer in a rat model.

• Smiles:

  O=C(C1=NC(N)=CC(=C1)NC=2C=CC=CC2O)N3CCN(C=4C=CC=CC4)CC3

• Molecular Formula:

  C22H23N5O2

• Molecular Weight:

  389.45

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2648407-76-3