I3IN-002

• Target :

  Apoptosis|||IGF-1R

• Related Pathways :

  Tyrosine Kinase/Adaptors|||Apoptosis

• Bioactivity :

  I3IN-002 is a small molecule inhibitor targeting the RNA-binding protein IGF2BP3, with an IC50 value of approximately 2 ?M in SEM cells. It disrupts the interaction with m6A-modified mRNA, destabilizing target genes (such as CDK6, MYC, and BCL2), thereby inhibiting the growth of leukemia cells, inducing cell cycle arrest, and promoting apoptosis. I3IN-002 shows potential for research in B-cell acute lymphoblastic leukemia.

• Smiles :

  O=C(NC=1C=CC=CC1C(F)(F)F)CSC=2N=NC3=C(N2)NC4=CC=C(C=C34)CC

• Molecular Formula :

  C20H16F3N5OS

• Molecular Weight :

  431.43

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  552829-57-9