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I3IN-002

CAT: 0931-T211133-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T211133-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
552829-57-9
Target
Apoptosis|||IGF-1R
Related Pathways
Tyrosine Kinase/Adaptors|||Apoptosis
Bioactivity
I3IN-002 is a small molecule inhibitor targeting the RNA-binding protein IGF2BP3, with an IC50 value of approximately 2 ?M in SEM cells. It disrupts the interaction with m6A-modified mRNA, destabilizing target genes (such as CDK6, MYC, and BCL2), thereby inhibiting the growth of leukemia cells, inducing cell cycle arrest, and promoting apoptosis. I3IN-002 shows potential for research in B-cell acute lymphoblastic leukemia.
Smiles
O=C(NC=1C=CC=CC1C(F)(F)F)CSC=2N=NC3=C(N2)NC4=CC=C(C=C34)CC
Molecular Formula
C20H16F3N5OS
Molecular Weight
431.43
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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