DJ-89

• Description :

  DJ-89 (Compound 77) is a potent soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 0.51 nM . DJ-89 inhibits sEH from hydrolyzing epoxyeicosatrienoic acids (EETs), reducing the production of pro-inflammatory substances. DJ-89 is promising for research of acute and chronic inflammatory diseases (such as rheumatoid arthritis) [1].

• UNSPSC :

  12352005

• Target :

  Epoxide Hydrolase

• Related Pathways :

  Metabolic Enzyme/Protease

• Field of Research :

  Inflammation/Immunology

• Smiles :

  COC1=CC(OC)=CC(CC(N2CCC(NC(NCC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)=O)=C1

• Molecular Formula :

  C24H28F3N3O5

• Molecular Weight :

  495.49

• References & Citations :

  [1]Ding J, et al. Discovery of Phenylacylpiperidine as Novel sEH Inhibitors through Scaffold Hopping of Natural Stilbene. J Med Chem. 2025 Apr 24;68 (8) :8980-9013.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported