DJ-89

CAT: 0804-HY-173568Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-173568Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DJ-89 (Compound 77) is a potent soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 0.51 nM . DJ-89 inhibits sEH from hydrolyzing epoxyeicosatrienoic acids (EETs), reducing the production of pro-inflammatory substances. DJ-89 is promising for research of acute and chronic inflammatory diseases (such as rheumatoid arthritis) [1].
UNSPSC
12352005
Target
Epoxide Hydrolase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Smiles
COC1=CC(OC)=CC(CC(N2CCC(NC(NCC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)=O)=C1
Molecular Formula
C24H28F3N3O5
Molecular Weight
495.49
References & Citations
[1]Ding J, et al. Discovery of Phenylacylpiperidine as Novel sEH Inhibitors through Scaffold Hopping of Natural Stilbene. J Med Chem. 2025 Apr 24;68 (8) :8980-9013.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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