DJ-89

• Description:

  DJ-89 (Compound 77) is a potent soluble epoxide hydrolase (sEH) inhibitor with an IC50 value of 0.51 nM . DJ-89 inhibits sEH from hydrolyzing epoxyeicosatrienoic acids (EETs), reducing the production of pro-inflammatory substances. DJ-89 is promising for research of acute and chronic inflammatory diseases (such as rheumatoid arthritis) [1].

• UNSPSC:

  12352005

• Target:

  Epoxide Hydrolase

• Related Pathways:

  Metabolic Enzyme/Protease

• Field of Research:

  Inflammation/Immunology

• Smiles:

  COC1=CC(OC)=CC(CC(N2CCC(NC(NCC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)=O)=C1

• Molecular Formula:

  C24H28F3N3O5

• Molecular Weight:

  495.49

• References & Citations:

  [1]Ding J, et al. Discovery of Phenylacylpiperidine as Novel sEH Inhibitors through Scaffold Hopping of Natural Stilbene. J Med Chem. 2025 Apr 24;68 (8) :8980-9013.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported