GPR84 agonist-2

• Description :

  GPR84 agonist-2 (Compound 8e) is a highly selective GPR84 agonist with an EC50 value of 7.24 nM. GPR84 agonist-2 activates the Gαq signaling pathway, promoting inositol trisphosphate (IP3) production and calcium release and enhancing neutrophil chemotaxis and pro-inflammatory cytokine release. GPR84 agonist-2 is promising for research of inflammatory diseases, such as ulcerative colitis and acute lung injury[1].

• UNSPSC :

  12352005

• Target :

  GPR84

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Purity :

  99.80

• Smiles :

  OC1=CC(OCC2CCCCC2)=NC(CCCCCCCCC)=C1

• Molecular Formula :

  C21H35NO2

• Molecular Weight :

  333.51

• References & Citations :

  [1]Ieremias L, et al. Minimal Structural Variation of GPR84 Full Agonist Causes Functional Switch to Inverse Agonism. J Med Chem. 2025 Apr 24;68 (8) :7973-8009.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  4°C (Powder, stored under nitrogen)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported