GPR84 antagonist 2

• Target :

  GPCR|||Others

• Related Pathways :

  GPCR/G Protein|||Endocrinology/Hormones|||Others

• Bioactivity :

  GPR84 Antagonist 2, a potent and selective GPR84 antagonist (IC 50 = 8.95 nM), demonstrates oral activity and significantly enhances potency in calcium mobilization assays. It effectively inhibits neutrophil and macrophage chemotaxis following GPR84 activation, highlighting its research potential for ulcerative colitis.

• Smiles :

  O=P(OC1=CC2=C(SC3=C1C=CC=C3)C=CC=C2Cl)(OC4=CC5=C(SC6=C4C=CC=C6)C=CC=C5Cl)[O-].[Na+]

• Molecular Formula :

  C28H16Cl2NaO4PS2

• Molecular Weight :

  605.42

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2244269-74-5