β-Glucuronidase-IN-3

• Description:

  β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric β-glucuronidase inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC50: 12.9 nM) . β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan (HY-16562) and nonsteroidal anti-inflammatory drugs (NSAIDs) [1].

• UNSPSC:

  12352005

• Target:

  Bacterial; β-glucuronidase

• Related Pathways:

  Anti-infection; Metabolic Enzyme/Protease

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C1N(C2=CNN=C2)[Se]C3=CC=CC=C31

• Molecular Formula:

  C10H7N3OSe

• Molecular Weight:

  264.14

• References & Citations:

  [1]Ying TT, et al. Optimized ebselen derivatives as novel potent Escherichia coli β-glucuronidase covalent allosteric inhibitors. Eur J Med Chem. 2025 Jun 5;290:117571.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3081681-34-4]