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β-Glucuronidase-IN-3

CAT: 0804-HY-173397Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-173397Size:1 Each
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Description
β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric β-glucuronidase inhibitor. β-Glucuronidase-IN-3 has potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) (IC50: 12.9 nM). β-Glucuronidase-IN-3 exerts its inhibitory effect by reversibly covalently modifying the cysteine residues (Cys28, Cys443, and Cys197) of EcGUS. β-Glucuronidase-IN-3 can be used in the study of intestinal microbiota-related diseases, especially to alleviate the toxic side effects of Irinotecan and nonsteroidal anti-inflammatory drugs (NSAIDs).
CAS Number
3081681-34-4
UNSPSC
12352005
Target
Bacterial; β-glucuronidase
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Field of Research
Metabolic Disease
Smiles
O=C1N(C2=CNN=C2)[Se]C3=CC=CC=C31
Molecular Formula
C10H7N3OSe
Molecular Weight
264.14
References & Citations
[1]Ying TT, et al. Optimized ebselen derivatives as novel potent Escherichia coli β-glucuronidase covalent allosteric inhibitors. Eur J Med Chem. 2025 Jun 5;290:117571.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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