β-Glucuronidase responsive conjugate 1

β-Glucuronidase responsive conjugate 1

• UNSPSC Description: β-Glucuronidase responsive conjugate 1 (compound 3) is a well-balanced photosensitizer which has photodynamic activity. β-Glucuronidase responsive conjugate 1 inhibits T-24 cell viability and growth with an IC50 of 0.2 μM. β-Glucuronidase responsive conjugate 1 can used to study bladder cancers[1].
• Target Antigen: Photosensitizer
• Type: Reference compound
• Related Pathways: Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/β-glucuronidase-responsive-conjugate-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1(CC1)C(NC2=CC=C(OC3=CC=NC4=CC(OCCOC(N(C)CCN(C(OCC5=CC=C(O[C@@H]6O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]6O)C=C5NC(CCC(NCCOCCOCCNC(C7=C(C)C8=CC9=[N]%10[Zn]%11%12N8C7=C(CC(OC)=O)C([C@@H](CCC(NCC%13=CN([C@H]%14[C@H](O)[C@@H](O)[C@H](O[C@H]%15O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%15O)[C@@H](CO)O%14)N=N%13)=O)[C@@H]%16C)=[N]%11C%16=CC%17=C(C)C(C=C)=C(N%17%12)C=C%10C(C)=C9CC)=O)=O)=O)=O)C)=O)=C(OC)C=C34)C=C2)=O)NC%18=CC=C(F)C=C%18
• Molecular Weight: 2277.63
• References & Citations: [1]Otvagin VF, et al. A first-in-class β-glucuronidase responsive conjugate for selective dual targeted and photodynamic therapy of bladder cancer. Eur J Med Chem. 2024 Mar 5;269:116283.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported