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β-Glucuronidase-IN-3

CAT: 0013-GTR19258144-01Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19258144-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
β-Glucuronidase-IN-3 (Compound 49) is a covalent allosteric inhibitor targeting β-glucuronidase. It exhibits potent inhibitory activity against Escherichia coli β-glucuronidase (EcGUS) with an IC50 of 12.9 nM. The compound exerts its inhibitory effect through reversible covalent modification of cysteine residues (Cys28, Cys443, and Cys197) on EcGUS. It is applicable in research on gut microbiota-related diseases, particularly in reducing the toxic side effects of Irinotecan and non-steroidal anti-inflammatory drugs (NSAIDs) .
CAS Number
3081681-34-4
Field of Research
Infectious Disease & Virology
Smiles
O=C1C=2C=CC=CC2[Se]N1C=3C=NNC3
Molecular Formula
C10H7N3OSe
Molecular Weight
264.14
Storage Conditions
-20°C
Notes
For research use only.

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