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BCN-E-BCN

CAT: 804-HY-173390Size: 1 EachDry Ice: NoHazardous: No
1 EachSelected
PRICE
AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BCN-E-BCN is a strained cycloalkyne-based probe designed for detecting protein sulfenylation, the primary intermediate in protein oxidation. This structurally constrained cycloalkyne compound specifically recognizes sulfenic acid groups formed during thiol oxidation, while remaining completely unreactive toward other oxidative states (such as free thiols, sulfinic, or sulfonic acid groups) . Researchers can leverage its efficient conjugation with azide-bearing tags through copper-free click chemistry to amplify detection signals. Compared to conventional detection methods, BCN-E-BCN demonstrates superior reaction kinetics and enhanced sensitivity. With these advantages, BCN-E-BCN shows great promise as an effective tool for protein oxidation research[1].
CAS Number
[2059099-03-3]
UNSPSC
12352211
Target
Biochemical Assay Reagents; Drug Intermediate
Related Pathways
Others
Field of Research
Others
Smiles
O=C(OC[C@H]1[C@@]2([C@]1(CCC#CCC2)[H])[H])NCCNC(OC[C@H]3[C@@]4([C@]3(CCC#CCC4)[H])[H])=O
Molecular Formula
C24H32N2O4
Molecular Weight
412.52
References & Citations
[1]McGarry DJ, et al. A Cell-Permeable Biscyclooctyne As a Novel Probe for the Identification of Protein Sulfenic Acids. ACS Chem Biol. 2016 Dec 16;11 (12) :3300-3304.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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