BMX-IN-3

• Description:

  BMX-IN-3 (B6a) is an irreversible and selective BMX inhibitor, with an IC50 of 12 nM. BMX-IN-3 (B6a) promots cell cycle arrest and apoptosis, triggers protective autophagy, and suppresses the BMX/AKT/mTOR pathway. BMX-IN-3 (B6a) can be used in the research for Gastric Carcinoma [1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy; BMX Kinase

• Related Pathways:

  Apoptosis; Autophagy; Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Smiles:

  NC1=NC(NC2=CC=CC(OC3=CC=CC=C3)=C2)=NC(N[C@@H]4CCCN(C4)S(C=C)(=O)=O)=N1

• Molecular Formula:

  C22H25N7O3S

• Molecular Weight:

  467.54

• References & Citations:

  [1]Nan Wang, Design, Synthesis, and Mechanism Study of Novel BMX Inhibitors Based on the Core of 1,3,5-Triazin-2-Amine for the Treatment of Gastric Carcinoma. J Med Chem. 2025 Feb 27;68 (4) :4196-4216.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2657662-64-9]