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NBM-T-BMX-OS01

CAT: 0804-HY-176498Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176498Size:1 Each
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Description
NBM-T-BMX-OS01 is an Osthole derivative. NBM-T-BMX-OS01 inhibits the phosphorylation of VEGFR2, FAK, Akt and ERK. NBM-T-BMX-OS01 has anti-angiogenic activity. NBM-T-BMX-OS01 has anti-cancer activity against colorectal cancer[1].
CAS Number
1246952-34-0
Product Name Alternative
BMX
UNSPSC
12352005
Target
Akt; FAK; PERK; VEGFR
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
COC(C=C1)=CC=C1COC2=C(C(OC)=CC=C2/C=C/C(NO)=O)C/C=C(C)\C
Molecular Formula
C23H27NO5
Molecular Weight
397.46
References & Citations
[1]Yang HY, et al. Anti-cancer activity of an osthole derivative, NBM-T-BMX-OS01: targeting vascular endothelial growth factor receptor signaling and angiogenesis. PLoS One. 2013 Nov 27;8 (11) :e81592.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VEGFR2/KDR/Flk-1

Chemical Information

NBM-T-L-BMX-OS01 (bmx)

HDAC8 Inhibitor NBM-BMX is an orally bioavailable inhibitor of histone deacetylase (HDAC) type 8 (HDAC8; HDAC-8), with potential antineoplastic activity. Upon administration, NBM-BMX targets and inhibits the activity of HDAC8. This results in an accumulation of highly acetylated chromatin histones, chromatin remodeling, and selective transcription of tumor suppressor genes, ultimately promoting cell-cycle arrest and induction of tumor cell apoptosis. HDAC8, a class 1 histone deacetylase, plays a key role in transcriptional regulation and cell cycle progression. Aberrant expression of HDAC8 or deregulated interactions with transcription factors may contribute to tumorigenesis. Isotype-selective HDAC inhibitors may be associated with fewer adverse effects compared to pan-HDAC inhibitors.

CAS Number1246952-34-0
PubChem CID46931326
IUPAC Name(E)-N-hydroxy-3-[4-methoxy-2-[(4-methoxyphenyl)methoxy]-3-(3-methylbut-2-enyl)phenyl]prop-2-enamide
Molecular FormulaC23H27NO5
Molecular Weight397.5
XLogP4.5
Topological Polar Surface Area77
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Heavy Atom Count29
Formal Charge0
Complexity549
SMILES
CC(=CCC1=C(C=CC(=C1OCC2=CC=C(C=C2)OC)/C=C/C(=O)NO)OC)C
InChI
InChI=1S/C23H27NO5/c1-16(2)5-12-20-21(28-4)13-8-18(9-14-22(25)24-26)23(20)29-15-17-6-10-19(27-3)11-7-17/h5-11,13-14,26H,12,15H2,1-4H3,(H,24,25)/b14-9+
InChIKey
SOWOYQPLOHLYEY-NTEUORMPSA-N
Chemical Structure
2D Structure
2D structure of NBM-T-L-BMX-OS01 (bmx)
CAS: 1246952-34-0
CID: 46931326
Formula: C23H27NO5
MW: 397.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight397.5
XLogP34.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count9
Exact Mass397.18892296
Monoisotopic Mass397.18892296
Topological Polar Surface Area77 Ų
Heavy Atom Count29
Formal Charge0
Complexity549
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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