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RJS308 (TFA)

CAT: 0804-HY-173011A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173011A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RJS308 TFA is the PROTAC degrader for cyclosporin A (CypA) with a DC50 of 284 nM. RJS308 TFA exhibits antiviral activcity through inhibition of HIV-1 and HCV replication[1].
UNSPSC
12352005
Target
Cyclophilin; HCV; HIV; PROTACs
Related Pathways
Anti-infection; Immunology/Inflammation; PROTAC
Applications
COVID-19-anti-virus
Field of Research
Infection
Purity
99.00
Smiles
C[C@@H](C1=CC=C(C2=C(C)N=CS2)C=C1)NC([C@H]3N(C[C@@H](C3)O)C([C@H](C(C)(C)C)NC(CCCCCN4N=NC(C[C@H]5C(N6N[C@@H](CCC6)C(O[C@H](C)C7=CC=C8C(C=C(C=C8)/C=C/CC(N[C@H](C(N5)=O)CC9=CC=C([N+]([O-])=O)C=C9)=O)=N7)=O)=O)=C4)=O)=O)=O.OC(C(F)(F)F)=O
Molecular Formula
C65H76F3N13O13S
Molecular Weight
1336.44
References & Citations
[1]Newton LS, et al., Macrocycle-based PROTACs selectively degrade cyclophilin A and inhibit HIV-1 and HCV. Nat Commun. 2025 Feb 10;16 (1) :1484.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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