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AZ3246

CAT: 0804-HY-173006-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-173006-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ3246 is an orally active and selective inhibitor of HPK1 with an IC50 of EC50 of 90 nM. AZ3246 is a low-clearance antitumor compound that can be used for the study of breast cancer[1].
CAS Number
2893978-54-4
UNSPSC
12352005
Target
Interleukin Related; MAP4K
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
98.92
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
FC(F)(CN1N=C(C)C(NC2=C(C(N)=O)N=C(C3=CN=CC4=C3N=CN4C)C(C5CC5)=N2)=C1)F
Molecular Formula
C21H20F3N9O
Molecular Weight
471.44
References & Citations
[1]Shields JD, et al. Discovery and Optimization of Pyrazine Carboxamide AZ3246, a Selective HPK1 Inhibitor. J Med Chem. 2025 Feb 27;68 (4) :4582-4595.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1

Chemical Information

CID 166485054
CAS Number2893978-54-4
PubChem CID166485054
IUPAC Name5-cyclopropyl-6-(3-methylimidazo[4,5-c]pyridin-7-yl)-3-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrazine-2-carboxamide
Molecular FormulaC21H20F3N9O
Molecular Weight471.4
XLogP1.9
Topological Polar Surface Area129
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity753
SMILES
CC1=NN(C=C1NC2=NC(=C(N=C2C(=O)N)C3=CN=CC4=C3N=CN4C)C5CC5)CC(F)(F)F
InChI
InChI=1S/C21H20F3N9O/c1-10-13(7-33(31-10)8-21(22,23)24)28-20-18(19(25)34)29-17(15(30-20)11-3-4-11)12-5-26-6-14-16(12)27-9-32(14)2/h5-7,9,11H,3-4,8H2,1-2H3,(H2,25,34)(H,28,30)
InChIKey
YLGMPWWMPCGYBF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of CID 166485054
CAS: 2893978-54-4
CID: 166485054
Formula: C21H20F3N9O
MW: 471.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight471.4
XLogP31.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count10
Rotatable Bond Count6
Exact Mass471.17429078
Monoisotopic Mass471.17429078
Topological Polar Surface Area129 Ų
Heavy Atom Count34
Formal Charge0
Complexity753
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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