Products for Research Use Only
RegisterLogin

AZ3146

CAT: 0804-HY-14710-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-14710-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AZ3146 is a reasonably potent Mps1 and TTK inhibitor, with IC50 of 35 nM for Mps1Cat.
CAS Number
1124329-14-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Mps1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ3146.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN(CC1)CCC1OC2=CC=C(NC3=NC(N(C4CCCC4)C(N5C)=O)=C5C=N3)C(OC)=C2
Molecular Formula
C24H32N6O3
Molecular Weight
452.55
Precautions
H302, H315, H319, H335
References & Citations
[1]Hewitt L, et al. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex. J Cell Biol. 2010 Jul 12;190 (1) :25-34.|[2]Liu X, et al. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells. Oncotarget. 2015 Oct 27;6 (33) :34309-20.|[3]Gurden MD, et al. Naturally Occurring Mutations in the MPS1 Gene Predispose Cells to Kinase Inhibitor Drug Resistance. Cancer Res. 2015 Aug 15;75 (16) :3340-54.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-173006-01AZ3246
HY-117724-01AZ3976
HY-117273-01AZ304
HY-112198-01AZ31

Alternative Products

CatalogName
A8372-100AZ3146
TBI4778-5MGAZ3146, Msp1 kinase inhibitor

Popular Products