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AZ304

CAT: 0804-HY-117273-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-117273-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ304 is an ATP-competitive dual BRAF kinase inhibitor, potently inhibits wild type BRAF, V600E mutant BRAF and wild type CRAF, with IC50s of 79 nM, 38 nM and 68 nM, respectively. AZ304 also has significant effect on other kinases, such as p38 (IC50, 6 nM), CSF1R (IC50, 35 nM) . Anti-tumor activity[1].
CAS Number
942507-42-8
Product Name Alternative
(2R,5S)-PF-06651600, PF-06651600 (malonate)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Autophagy; Raf
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/AZ304.html
Purity
99.77
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=CC=C(C)C(NC2=C3C=CC(OC)=CC3=NC=N2)=C1)C4=CC=CC(C(C)(C#N)C)=C4
Molecular Formula
C27H25N5O2
Molecular Weight
451.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Ma R, et al. AZ304, a novel dual BRAF inhibitor, exerts anti-tumour effects in colorectal cancer independently of BRAF genetic status. Br J Cancer. 2018 May;118 (11) :1453-1463.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
B-Raf; C-Raf

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BA3649-100AZ304
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A17225-50AZ304 50mg
A17225-10AZ304 10mg
A17225-25AZ304 25mg
A17225-5AZ304 5mg
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