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GluN1/3A-IN-1

CAT: 0804-HY-172997-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-172997-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GluN1/3A-IN-1 (Compound GM-10) is a GluN1/GluN3A NMDA receptor inhibitor. GluN1/3A-IN-1 exhibits potent inhibitory activity against GluN1/GluN3A (IC50: 0.98 µM) . GluN1/3A-IN-1 exerts its inhibitory effect by targeting the pre-M1 region and forming hydrogen bond interactions with key residues. GluN1/3A-IN-1 can be used to study GluN1/GluN3A-related neurological diseases[1].
CAS Number
1147526-22-4
UNSPSC
12352005
Target
IGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Purity
98.06
Smiles
O=C(C1=C(C=C(C=C1)O)O)OCC(C2C(C3=CC=CC=C3)=NC4=C2C=CC=C4)=O
Molecular Formula
C23H17NO5
Molecular Weight
387.38
References & Citations
[1]Wang SH, et al. Discovery of novel GluN1/GluN3A NMDA receptor inhibitors using a deep learning-based method. Acta Pharmacol Sin. 2025 May 12.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

[2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl] 2,4-dihydroxybenzoate
CAS Number1147526-22-4
PubChem CID40190988
IUPAC Name[2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl] 2,4-dihydroxybenzoate
Molecular FormulaC23H17NO5
Molecular Weight387.4
XLogP4.8
Topological Polar Surface Area99.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count29
Formal Charge0
Complexity590
SMILES
C1=CC=C(C=C1)C2=C(C3=CC=CC=C3N2)C(=O)COC(=O)C4=C(C=C(C=C4)O)O
InChI
InChI=1S/C23H17NO5/c25-15-10-11-17(19(26)12-15)23(28)29-13-20(27)21-16-8-4-5-9-18(16)24-22(21)14-6-2-1-3-7-14/h1-12,24-26H,13H2
InChIKey
RISXIGZCAZRKCG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of [2-oxo-2-(2-phenyl-1H-indol-3-yl)ethyl] 2,4-dihydroxybenzoate
CAS: 1147526-22-4
CID: 40190988
Formula: C23H17NO5
MW: 387.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight387.4
XLogP34.8
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass387.11067264
Monoisotopic Mass387.11067264
Topological Polar Surface Area99.6 Ų
Heavy Atom Count29
Formal Charge0
Complexity590
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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