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GluN1 Antibody (APC)

CAT: 0013-GTR18028899Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0013-GTR18028899Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mouse monoclonal to GluN1-NR1 (APC) . The NMDA receptor (NMDAR), a glutamate receptor, is the predominant molecular device for controlling synaptic plasticity and memory function. The NMDA receptor forms a heterotetramer between two NR1 and two NR2 subunits (the subunits are also called glutamate-binding NMDA receptor subunits or GluN for short) ; two obligatory NR1 subunits and two regionally localized NR2 subunits. A related gene family of NR3 A and B subunits have an inhibitory effect on receptor activity. Multiple receptor isoforms with distinct brain distributions and functional properties arise by selective splicing of the NR1 transcripts and differential expression of the NR2 subunits..
Product Name Alternative
GRIN1, GluN1, Glutamate [NMDA] receptor subunit zeta-1, Glutamate receptor ionotropic N methyl D aspartate 1, MRD8, Methyl-D-aspartate receptor subunit zeta-1, N methyl D aspartate receptor, N methyl D aspartate receptor channel subunit zeta 1, N methyl D aspartate receptor subunit NR1, NMD-R1, NMDA 1, NMDA R1, NMDA Receptor 1, NMDA1, NMDAR, NMDAR1, NMDZ1_HUMAN, NR1
UniProt
P35439
Reactivity
Human, Mouse, Rat
Immunogen
Fusion protein amino acids 42-361 (extracellular N-terminus) of rat NR1
Target
GluN1
Clonality
Monoclonal
Clone
N308/48
Conjugation
APC
Field of Research
Neuroscience
Purification
Protein G Purified
Concentration
1 mg/ml
Dilution
WB (1:1000), IHC (1:1000), ICC/IF (1:100)
Molecular Weight
105kDa
Storage Conditions
Conjugated antibodies should be stored according to the product label
Notes
For research use only.
Applications Notes
1 μg/ml was sufficient for detection of NR1 glutamate receptor in 20 μg of rat brain membrane lysate and assayed by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
Tested Applications
ICC, IF, IHC, WB
NCBI Accession Number
NP_058706.1
Host or Source
Mouse
Preservative
95.46mM Phosphate, 2.48mM MES and 2mM EDTA
Isotype
IgG1
Entrez
24408

UniProtKB · P35439

Glutamate receptor ionotropic, NMDA 1

NMDZ1_RAT · Rattus norvegicus

View on UniProt ↗
Primary accession
P35439
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
Grin1
Protein existence
1: Evidence at protein level
Organism
Rattus norvegicus (Rat)
Taxonomy ID
10116
Alternative names
GluN1
EC number
—
Processing
Precursor
Secondary accessions
Q62646
Protein keywords

Technical term

3D-structureReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMagnesiumMetal-bindingZinc

Cellular component

Cell membraneMembranePostsynaptic cell membraneSynapse

PTM

Disulfide bondGlycoproteinIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

Ion channelLigand-gated ion channelReceptor

Biological process

Ion transportTransport

Domain

SignalTransmembraneTransmembrane helix

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