IQM-266

• Description :

  IQM-266 is a Downstream Regulatory Element Antagonist Modulator (DREAM) ligand with a KD of 4.63 μM. IQM-266 inhibits the KV4.3/DREAM current in a concentration-, voltage-, and time-dependent-manner. IQM-266 also modulates A-type outward potassium currents (IA) from rat dorsal root ganglia (DRG) neurons. IQM-266 can be used for neurological disease research, such as Alzheimer’s disease and Huntington's disease (HD) [1].

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Neurological Disease

• Purity :

  99.42

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  O=C(NC1=CC(C=CC=C2)=C2C=C1C(O)=O)CC3=CC(OC4=CC=CC=C4)=CC=C3

• Molecular Formula :

  C25H19NO4

• Molecular Weight :

  397.42

• References & Citations :

  [1]Peraza DA, et al. Identification of IQM-266, a Novel DREAM Ligand That Modulates KV4 Currents. Front Mol Neurosci. 2019 Feb 4;12:11.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1956337-58-8]