DA-302168S

• Description:

  DA-302168S is an orally active and selective agonist targeting the GLP-1R, with EC50 value of 1.32 nM. DA-302168S stimulates insulin secretion and shows hypoglycemic effects. DA-302168S decreases food intake. DA-302168S mainly activates GLP-1R of monkeys and humans, and exhibits little excitatory effect on GLP-1R of rats, mice, and dogs. DA-302168S can be used for type 2 diabetes and obesity study[1].

• UNSPSC:

  12352101

• Target:

  GCGR

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C(C1=CC2=C(N=C(N2C[C@@H]3CCO3)CC4=CC=C(C=C4F)C5=NC(OCC6=CC=C(C7=C6OC=C7)Cl)=C(C=C5)F)C=C1)O

• Molecular Formula:

  C33H24ClF2N3O5

• Molecular Weight:

  616.01

• References & Citations:

  [1]Dong G, et al. Discovery and Evaluation of DA-302168S as an Efficacious Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist. J Med Chem. 2025 May 8;68 (9) :9555-9583.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [2969158-02-7]