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DA-302168S

CAT: 0804-HY-172811Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172811Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DA-302168S is an orally active and selective agonist targeting the GLP-1R, with EC50 value of 1.32 nM. DA-302168S stimulates insulin secretion and shows hypoglycemic effects. DA-302168S decreases food intake. DA-302168S mainly activates GLP-1R of monkeys and humans, and exhibits little excitatory effect on GLP-1R of rats, mice, and dogs. DA-302168S can be used for type 2 diabetes and obesity study[1].
CAS Number
2969158-02-7
UNSPSC
12352101
Target
GCGR
Related Pathways
GPCR/G Protein
Field of Research
Metabolic Disease
Smiles
O=C(C1=CC2=C(N=C(N2C[C@@H]3CCO3)CC4=CC=C(C=C4F)C5=NC(OCC6=CC=C(C7=C6OC=C7)Cl)=C(C=C5)F)C=C1)O
Molecular Formula
C33H24ClF2N3O5
Molecular Weight
616.01
References & Citations
[1]Dong G, et al. Discovery and Evaluation of DA-302168S as an Efficacious Oral Small-Molecule Glucagon-Like Peptide-1 Receptor Agonist. J Med Chem. 2025 May 8;68 (9) :9555-9583.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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