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NBTI 5463

CAT: 0804-HY-172229Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-172229Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NBTI 5463 is a bacterial type II topoisomerases (topoisomerase II) inhibitor with antibacterial activity. NBTI 5463 inhibits GyrA and TopoIV in Pseudomonas aeruginosa and Escherichia coli. NBTI 5463 binds to topoisomerase II to prevent DNA cleavage and religation, inhibiting bacterial DNA replication and transcription. NBTI 5463 is promising for research of Gram-negative bacterial infection[1].
CAS Number
1227303-03-8
UNSPSC
12352005
Target
Bacterial; Topoisomerase
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
COVID-19-anti-virus
Field of Research
Infection
Smiles
N[C@H]([C@@]1([H])CC[C@@H](CC1)NCC2=CC=C(OCC(N3)=O)C3=N2)CN4C5=CC(OC)=CN=C5C=CC4=O
Molecular Formula
C25H30N6O4
Molecular Weight
478.54
References & Citations
[1]Nayar AS, et al. Target-based resistance in Pseudomonas aeruginosa and Escherichia coli to NBTI 5463, a novel bacterial type II topoisomerase inhibitor. Antimicrob Agents Chemother. 2015 Jan;59 (1) :331-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II

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